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Welcome to the Chedin Laboratory
_____We are studying the function of mammalian DNA methyltransferases. These enzymes, through their ability to silence gene activity in a heritable manner, contribute to set a form of epigenetic cellular memory. DNA methyltransferases are strictly required for normal embryonic development and play important roles in key biological processes such as X-inactivation and genomic imprinting. Aberrant methylation of tumor suppressor genes or of oncogenes has now been established as a leading cause for human cancers.
We are using a combination of approaches (biochemistry, tissue culture, mouse model studies) to study the function of
DNA methyltransferases in mammalian cells.
We are affiliated with the following Institutions, Departments, and Graduate Programs.
- Contact Info:
- Frédéric Chédin
Section of Molecular & Cellular Biology
The University of California at Davis
One Shields Ave.
Davis, CA 95616
flchedin@ucdavis.edu
Epigenetics in the News
| November, 2007 |
WEBCAST: Epigenetics - Playing the Genetic Score |
| Epigenetics is challenging long-held notions that our genes are our destiny and radically changing the
way researchers think about the development of certain illnesses. As science come to understand the way epigenetic processes silence genes,
it is given rise to promising new therapies for diseases such as MDS.
-The Journal of Life Sciences, Sponsored by Pharmion
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| August, 2007 |
UCSF Scientists Aim to Use Saliva to Detect Oral Cancers |
| Could scrutiny of spit save your life? Cancer researchers may soon know the answer. More than 30,000 new cases
of oral cancer are diagnosed each year in the US alone, many when it’s too late to prevent death. Dentists and hygienists find oral cancers during
exams, but researchers at UCSF now are developing ways to detect cancers earlier — before tumors become visible to the naked eye.To do so they are
examining telltale proteins in saliva.
-Rachel Tompa, UCSF Today, August 21, 2007
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| February, 2007 |
'Asterisks' in the DNA |
| What makes you different from everyone else on the planet may have less to do with the spelling of your
genetic code than with a scattering of chemical "tags" that, like censor's marks, render some of your genes unreadable. The code itself, after all,
is 99.9 percent identical in all of us, so these peripheral elements - referred to as epigenetics - offer a plausible reason human beings come in
such a variety of shapes and sizes.
-Faye Flam, The Philadelphia Inquirer, February 12, 2007
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| January, 2007 |
Scientists discover stage at which cells are fated to become stem cells |
| Cambridge scientists have discovered the stage at which some of the cells of a fertilised mammalian egg are
fated to develop into stem cells and why this occurs. The findings of the study, which overturn the long-held belief that cells are the same until
the fourth cleavage (division) of the embryo, are reported in this week's edition of Nature.
-University of Cambridge, January 13, 2007
You can link to the primary research article here.
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| January, 2007 |
Study Supports A Stem Cell Origin Of Cancer |
| Researchers at the University of Southern California (USC) recently made significant strides toward settling a
decades-old debate centering on the role played by stem cells in cancer development. According to the study's findings, which appear in an upcoming
issue of Nature Genetics and now available online, genes that are reversibly repressed in embryonic stem cells are over-represented among genes that are
permanently silenced in cancers; this link lends support to the increasingly discussed theory that cancer is rooted in small populations of stem cells.
-Medical News Today, January 11, 2007
You can link to the primary research article here.
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| December, 2006 |
Scientists Developing Lung Cancer Breath Test |
| A simple breath test could someday help predict who's at highest risk of getting lung cancer. In preliminary
research, the breath test was successful in finding cancer "markers," said senior researcher Dr. Simon D. Spivack, a pulmonologist at the Wadsworth
Center, the public health laboratory of the New York State Department of Health. That's important, he added, because "lung cancer [typically] exists
for a decade or two before it is diagnosed."
-Forbes.com, December 12, 2006
You can link to the primary research article here.
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| October, 2006 |
Cell Differentiation No Barrier to Cloning |
| Dolly the cloned ewe has been at the center of controversy since she was announced to the world in 1997. Beneath
the philosophical considerations, the science of the cloning feat--in particular the type of cell used to kick off the process--has been an issue of
some debate. Some have argued that so-called adult stem cells--root cells in most tissue that kick into action to replace damaged tissue--must have been
involved. But a new test in mice shows that adult stem cells are actually worse than regular cells for the purposes of cloning with current techniques.
-David Biello, Scientific American, October 1, 2006
You can link to the primary research article here.
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| September, 2006 |
Learning without learning |
| Freud was famously preoccupied with the influence of early childhood experiences on development. His theory of
psychoanalysis, which provided a new approach to the analysis and treatment of abnormal adult behaviour, has attracted both ardent followers and fierce
critics. According to this theory, the unconscious mind carries imprints of the past that mercilessly haunt the present. Unearthing those imprints is the
key to understanding what is going on and then treating it.
-The Economist, September 21, 2006
You can link to the primary research article here.
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Past Articles |
| Since the news sources that we are linking to are constantly moving their articles, please report any dead links
here |
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