Selected Publications
Hu, W., Su, Y-S. and Lagarias, J.C. (2009) A light-independent allele of phytochrome B faithfully recapitulates photomorphogenic transcriptional networks. Molecular Plant, 2, 166-182; doi:10.1093/mp/ssn086 [abstract]
Stoll, S., Gunn, A., Brynda, M., Sughrue, W., Kohler, A., Ozarowski, A., Fisher, A., Lagarias, JC.; and Britt, R. D. (2009) The structure of the biliverdin radical intermediate in phycocyanobilin:ferredoxin oxidoreductase identified by high-field EPR and DFT. J. Am. Chem. Soc. 131, 1986-1995. [abstract]
Rockwell, N.C., Njuguna, S.L., Dwojak, S., Castillo, E., Roberts, L., Parson, V.L, Lagarias, J.C, and Spiller, S.S. (2008) A second conserved GAF domain cysteine is required for the blue/green photoreversibility of cyanobacteriochrome Tlr0924 from Thermosynechococcus elongatus. Biochemistry, 47, 7304-7316. [abstract]
Su, Y-S. and Lagarias, J.C. (2007) Light independent phytochrome signaling mediated by dominant GAF-domain tyrosine mutants of Arabidopsis phytochromes in transgenic plants, Plant Cell (USA) 19, 2124–2139. [abstract]
Rockwell, N. C., and Lagarias, J.C. (2007) HOMOLMAPPER: Visualizing homology on a known protein structure. BMC Bioinformatics, 8:123, doi:10.1186/1471-2105-8-123. [abstract]
Rockwell, N. C., Su, Y-S., and Lagarias, J.C. (2006) Phytochrome structure and signaling mechanisms, Annual Review of Plant Biology 57, 837-858. [abstract]
Miller, A.E., Fischer, A.J., Laurence, T.A., Hollars, C.W., Saykally, R.J., Lagarias, J.C. and Huser,T. (2006) Single molecule dynamics of phytochrome-bound fluorophores probed by fluorescence correlation spectroscopy. Proc. Natl. Acad. Sci. (USA) 103, 11136-11141. [abstract]
Rockwell, N. C., and Lagarias, J.C. (2006) The structure of phytochrome. A picture is worth a thousand spectra. Plant Cell 18, 4-14. [abstract]
Tu, S-L., Sughrue, W. L., Britt, R.D. and Lagarias, J.C. (2006) A conserved histidine-aspartate pair is required for exovinyl reduction of biliverdin by a cyanobacterial phycocyanobilin:ferredoxin oxidoreductase. J. Biol. Chem. 281, 3127-3136. [abstract]
Fischer, A.J., Rockwell, N.C., Jang, A., Ernst, L., Waggoner, A., Duan, Y., Lei, H-X. and Lagarias, J.C. (2005) Multiple roles of a conserved GAF domain tyrosine residue in cyanobacterial and plant phytochromes. Biochemistry 44, 15203-15215. [abstract]
Fischer, A.J. and Lagarias, J.C. (2004) Harnessing Phytochrome's Glowing Potential. Proc. Natl. Acad. Sci (USA) 101, 17334-17339. [abstract]
Tu, S-L., Gunn, A., Toney, M.D., Britt, R.D. and Lagarias, J.C. (2004) Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates. J. Am. Chem. Soc. 126, 8682-8693. [abstract]
Kami, C., Mukougawa, K., Muramoto, T., Yokota, A., Shinomura, T., Lagarias, J.C. and Kohchi, T. (2004) Complementation of Phytochrome Chromophore-Deficient Arabidopsis by Expression of Phycocyanobilin:Ferredoxin Oxidoreductase Proc. Natl. Acad. Sci (USA) 101, 1099-1104. [abstract]
Terauchi, K., Montgomery, B.L., Grossman, A.R., Lagarias, J.C., and Kehoe, D.M. (2004) RcaE is a Complementary Chromatic Adaptation Photoreceptor Required for Green and Red Light Responsiveness Molecular Microbiology 51, 567-577. [abstract]
Franklin, K.A., Linley, P.J., Montgomery, B.L., Lagarias, J.C., Thomas, B., Jackson, S.D. and Terry, M.J. (2003) Misregulation of the tetrapyrrole biosynthesis in transgenic tobacco expressing mammalian biliverdin reductase. Plant Journal 35, 717-728. [abstract]
Frankenberg, N. and Lagarias J.C. (2003) Phycocyanobilin:ferredoxin oxidoreductase (PcyA) of Anabaena sp. PCC 7120. Biochemical and spectroscopic characterization. J. Biol. Chem. 278, 9219-9226. [abstract]
Montgomery, B.L. and Lagarias, J.C. (2002) Phytochrome ancestry: Sensors of bilins and light. Trends in Plant Sciences 7, 357-66. [abstract]
Frankenberg, N., Mukougawa, K., Kohchi, T., and Lagarias J.C. (2001) Functional Genomic Analysis of the HY2 Family of Ferredoxin-Dependent Bilin Reductases from Oxygenic Photosynthetic Organisms Plant Cell 13, 965-978. [abstract]
McDowell, M.T. and J.C. Lagarias (2001) Purification and biochemical properties of phytochromobilin synthase (Biliverdin:Ferredoxin 2,3-oxidoreductase) from etiolated oat seedlings. Plant Physiol.126, 1546-1554.
[abstract]
Gambetta, G.A., and Lagarias, J.C. (2001) Genetic engineering of phytochrome biosynthesis in bacteria. Proc. Natl. Acad. Sci. 98, 10566-10571. [abstract]
Kohchi, T., Mukougawa, K., Frankenberg, N., Masuda, M., Yokota, A., and Lagarias, J.C. (2001) The Arabidopsis HY2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase. Plant Cell 13, 425-436. [abstract]
Montgomery, B.L., K. A. Franklin, M.J. Terry, B. Thomas, S. Jackson, M.W. Crepeau, and J.C. Lagarias (2001) Biliverdin reductase induced phytochrome chromophore-deficiency in transgenic Nicotiana tabacum cv. Maryland Mammoth. Plant Physiol. 125, 266-277. [abstract]
Andel, F. III, J.T. Murphy, J. A. Haas, M.T. McDowell, I.van der Hoef, J. Lugtenburg, J.C. Lagarias and R.A. Mathies (2000) Probing the photoreaction mechanism of phytochrome through analysis of resonance Raman vibrational spectra of recombinant analogs. Biochemistry 39, 2667-2676. [abstract]
Wu, S-H. and J.C. Lagarias. (2000) Defining the bilin lyase domain: Lessons from the extended phytochrome superfamily, Biochemistry 39, 13487-13495. [abstract]
Montgomery, B.L., K-C. Yeh, M.W. Crepeau, and J.C. Lagarias (1999) Modification of distinct aspects of photomorphogenesis via targeted expression of mammalian biliverdin reductase in transgenic Arabidopsis plants. Plant Physiol. 121, 629-639. [abstract]
Fankhauser, C., K.-C. Yeh, J. C. Lagarias, H. Zhang, T. D. Elich and J. Chory (1999) PKS1, a substrate phosphorylated by phytochrome that modulates light signaling in Arabidopsis.Science 284, 1539-1541. [abstract]
Nozue, K., T. Kanegae, T. Imaizumi, S. Fukuda, H. Okamoto, K-C.Yeh, J.C.Lagarias and M. Wada (1998) A novel phytochrome from the fern Adiatum with features of NPH1. Proc. Natl. Acad. Sci (USA) 95, 15826-15830. [abstract]
Yeh, K.-C., and Lagarias, J. C. (1998) Eukaryotic Phytochromes: Light-Regulated Serine/Threonine Protein Kinases with Histidine Kinase Ancestry. Proc. Natl. Acad. Sci. USA 95, 13976-13981. [abstract]
Lagarias, D.M., M.W. Crepeau, M.D. Maines and J.C. Lagarias (1997) Regulation of photomorphogenesis by expression of mammalian biliverdin reductase in transgenic Arabidopsis plants. Plant Cell 9, 675-788. [abstract]
Murphy, J.T. and J.C. Lagarias (1997) The Phytofluors: A New Class of Fluorescent Protein Probes. Current Biology 7: 870-876. [abstract]
Murphy, J.T. and J.C. Lagarias (1997) Purification and characterization of recombinant affinity peptide-tagged oat phytochrome A. Photochemistry and Photobiology 65, 750-758. [abstract]
Wu, S-H. , M.T. McDowell and J.C. Lagarias (1997) Phycocyanobilin is the natural chromophore precursor of phytochrome in the green alga Mesotaenium caldariorum. J. Biol. Chem. 272, 25700-25705. [abstract]
Yeh, K-C., S-H. Wu, J. T. Murphy and J. C. Lagarias (1997) A cyanobacterial phytochrome two-component light sensory system. Science 277, 1505-1508. [abstract]