MCB 143: SELECTED READING LIST.

(The original papers will be periodically supplemented with hand-outs from textbooks as indicated below)

Lecture 1: Physical Properties of the Intracellular Environment

- Bray, D (2001) Cell Movements: From Molecules to Motility. Chapter 1, Cell Swimming, pages 3-8. PDF
- Purcell, E. (1977) Life at Low Reynold’s number. Amer. J. Phys. 45; 3-11. PDF
- Oster, G. (2002) Darwin’s motors. Nature, 417; 25 PDF

- Howard Berg (1993) Random Walks in Biology, pages 48-50. PDF

Lectures 2 and 3: Quantum Mechanics and Chemical Bonding

- Watson, J.D. (1970)  Small Biomolecules and Important Functional Groups. In Molecular Biology of the Gene (2nd Ed). Tables 2.1 and 2.2. PDF
- Whittaker, Mount and Heal (2000) Physical Chemistry, (Springer Pubs): PDF
    Section G - Quantum Nature of the Physical World
    Section H - Bonding.

Lecture 4: From Molecules to Macromolecular Assemblies

- Watson, J. D. and Crick, F. H. C. (1953) A Structure for Deoxyribose Nucleic Acid. Nature, 171, 737. PDF
- Crick, F.H.C. (1970) Central Dogma of Molecular Biology. Nature, 227, 561-563. PDF

- Watson, J.D. (1970)The importance of weak chemical interactions. In Molecular Biology of the Gene (2nd Ed). pp102-140. PDF

Lecture 5: Macromolecular Assemblies and Protein Machines

- Crick, F.H.C and Watson J.D (1956) Structure of Small Viruses. Nature, 177, 473-475. PDF

- Huxley, H.E. (1963) Electron Microscope studies on the structure of natural and synthetic protein filaments from striated muscle. Journal of Molecular Biology, 7. 281-308. PDF

- Alberts, B. (1998) The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists. Cell 92: 291–294. PDF

Lecture 6: The Protein Machinery of Cell Motility and Division.

- Bray, D (2001) Cell Movements: From Molecules to Motility. Chapter 1, Cell Swimming.

- Pollard TD (2003) The cytoskeleton, cellular motility and the reductionist agenda. Nature, 422, 741-745. PDF

- Scholey, J.M., Brust-Mascher, I., Mogilner A. (2003) Cell division. Nature. 422:746-752. Review. PDF
 

Lecture 7: Microscopy and Motility Assays

- Spencer, M. (1982). Fundamentals of Light Microscopy. Cambridge University Press.

    Chapter 2, Properties of Light

    Chapter 5, Bright Field, Phase and Dark-field Microscopy

    Chapter 6, Fluorescence Microscopy.

- Rogers and Scholey (2004) Motility Assays for Microtubule Motor Proteins. Nature Encyclopedia of Life Sciences.  PDF
- Kapitein et al (2005) The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435: 114-118. PDF

Lecture 8: Diffusion

- Howard Berg (1993) Random Walks in Biology,

    Chapter 1, Diffusion: Microscopic Theory

    Chapter 4. Diffusion with drift

    Chapter 6, Movement of Self-propelled Objects.

Lectures 9, 10: Microtubule and Actin Dynamics

- Mogilner, A, and Oster, G. (2003) Polymer motors: pushing out the front and pulling up the back. Current Biology, 13; R721-R733. PDF
- Wegner, A. (1976) Head to tail polymerization of actin. Journal of Molecular Biology. 108: 139-150.
- Walker et al (1988) Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies. Journal of Cell Biology. 107: 1437-1448. PDF

Lecture 11: Molecular Motors

- Vale, R.D. and Milligan, R.M. (2000) The way things move: Looking under the hood of molecular motors. Science, 288; 88-95. PDF
- Vale et al (1985) Identification of a novel force generating protein, kinesin, involved in microtubule-based motility. Cell, 42: 39-50.PDF
- Lawrence, C. et al (2004) A Standardized Kinesin Nomenclature. J. Cell Biol. 167; 19-22. PDF

Lecture 12 : Nucleotide Chemistry

- Fisher et al. (1995) X-ray Structures of the Myosin Motor Domain of Dictyostelium discoideum Complexed with MgADPBeF, and MgADPAlF4. Biochemistry 34: 8960-8972. PDF

Lectures 13, 14: Intracellular and Intraflagellar Transport

- Vale, R.D. (2003) The Molecular Motor Toolbox for Intracellular Transport. Cell, 112; 467-480. PDF

- Scholey, J.M. (2003) Intraflagellar Transport. Ann. Rev. Cell Dev. Biol. 19; 423-443. PDF

- Cole, DG et al. (1998) Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons.  J Cell Biol. 141: 993-1008.  PDF
- Pan, X., et al (2006) Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J. Cell. Biol. 174(7):1035-45. PDF

Lecture 15, 16: Muscle Contraction

- Huxley and Hanson (1954) Changes in the Cross-Striations of Muscle during Contraction and Stretch and their Structural Interpretation.  Nature, 173: 973- 976. PDF
- Huxley (2004) Fifty years of muscle and the sliding filament hypothesis. Eur. J. Biochem. 271, 1403–1415. PDF
- Finer et al (1994) Single myosin molecule mechanics: piconewton forces and nanometre steps. Nature 368: 113-119PDF
- Lymm and Taylor (1971) Mechanism of adenosine triphosphate hydrolysis by actomyosin. Biochemistry 10: 4617-4624. PDF

Lectures 17-19: Mechanisms of Mitosis

- History of Mitosis PowerPoint PPT

- Heald R (2007) BrinkleyFest of mitosis. Developmental Cell, 13; 168-176. PDF

- Kapitein et al (2005) The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435: 114-118. PDF

- Tao et al (2006) A Homotetrameric Kinesin-5, KLP61F, Bundles Microtubules and Antagonizes NCD in Motility Assays. Current Biology, 16; 2293 - 2302 PDF
- Rogers, G.C. et al (2004) Two Mitotic Kinesins Cooperate to Drive Sister Chromatid Separation During Anaphase. Nature 427; 364-370. PDF

 

Lectures 20, 21: Modeling Mitosis

- Modeling Mitosis PowerPoint PPT

- Gardner M.K. and Odde, D.J. (2006) Modeling of chromosome motility during mitosis. Current Opinion in Cell Biology 18, 639-647 PDF

- Brust-Mascher, I. et al (2004) Model for Anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongation. Proc. Natl. Acad. Sci. (USA) 101: 15938-15943. PDF.

- Cheerambathur et al (2007) Quantitative Analysis of an Anaphase B switch: predicted role for a microtubule catastrophe gradient. J. Cell Biol., 177: 995 - 1004. PDF

- Civelekoglu-Scholey et al (2006) Model of chromosome motility in Drosophila embryos: Adaptation of a general Mechanism for Rapid Mitosis. Biophysical Journal. 90: 3966-3982. PDF

- Burbank, Mitchison and Fisher (2007) Slide and Cluster Models for Spindle Assembly. Current Biology. 17: 1373 -1383. PDF