The research of our laboratory is focused on the molecular mechanisms of microtubule-based motor protein function during intracellular transport and mitosis.
Our two major projects are:
1. Intraflagellar Transport Motors and Sensory Ciliogenesis on C. elegans Neurons. Featured in UC Davis news.
2. Dynamics and Mechanics of Mitosis in Drosophila: Mechanisms of Anaphase B.
These projects combine studies of the basic biochemistry and molecular biology of microtubules and microtubule-based motors, high resolution time-lapse microscopy of motor action in sensory cilia and mitotic spindles in vivo, and quantitative modeling. We hope that this combination of approaches will illuminate the molecular and biophysical principles underlying the roles of microtubule motors in building subcellular machines and the mechanism of action of the protein machines that carry out mitosis, intraflagellar transport and other critical subcellular processes.
University of California, Davis- Dept. of Molecular & Cellular Biology, One Shields Ave. Davis, CA 95616
This homepage is maintained by: Ingrid Brust-Mascher