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The electron microscope is an extremely valuable tool in biomedical research. It can be used to determine the shape of biologically important macromolecules, sometimes with atomic resolution. Aditionally, three-dimensional information provided by electron microscopy and image reconstruction is often used to piece together large protein complexes, for which the structures of the component molecules have been determined by X-ray crystallography or other methods. The University of California, Davis, has a state-of the art electron microscopy facility, located at the basement of Briggs Hall, in the Department of Molecular and Cellular Biology. This facility is equipped with the necessary tools to carry out research projects aiming to visualize interactions at the molecular level, or the ultrastructural arrangement of cellular components. In addition, we can provide local expertise for data analysis and experiment planification.