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Preprints (our latest work!)


Oncogenic mutant RAS activity is rescaled by the ERK/MAPK pathway (2020)

Gillies T, Pargett M, Silva JM, Teragawa C, McCormick F, Albeck JG

bioRxiv doi: https://doi.org/10.1101/2020.02.17.952093 Link

Cell-to-cell variability in AMPK activation reveals autonomous cycles in cellular energy balance (2019)

Kosaisawe N, Sparta B, Pargett M, Teragawa C, Albeck JG

bioRxiv doi: https://doi.org/10.1101/780023 Link

Systems-level properties of EGFR/RAS/ERK signaling amplify local signals to generate dynamic gene expression heterogeneity (2019)

Davies AE, Gillies TE, Siebert S, Pargett M, Tobin SJ, Ram AR, Juliano C, Quon G, Bissell MJ, Albeck JG

bioRxiv doi: https://doi.org/10.1101/466656 Link Data


Methods (useful protocols for single-cell dynamics)


Live-Cell Imaging and Analysis with Multiple Genetically Encoded Reporters (2018)

Pargett M, Albeck JG

Current Protocols in Cell Biology 78(1):4.36.1-4.36.19. Link

Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors (2017)

Pargett M, Gillies TE, Teragawa CK, Sparta B, Albeck JG

Methods in Molecular Biology 1636:35-59 Link

Primary Papers


Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases (2018)

Sampattavanich S, Steiert B, Kramer BA, Gyori BM, Albeck JG, Sorger PK

Cell Systems doi: 10.1016/j.cels.2018.05.004. Link

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells (2017)

Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG

Elife doi: 10.7554/eLife.27293. Link

Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation (2017)

Gillies TE, Pargett M, Minguet M, Davies AE, Albeck JG

Cell Systems doi: 10.1016/j.cels.2017.10.019 Link Data

Entosis Is Induced by Glucose Starvation (2017)

Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M

Cell Reports doi: 10.1016/j.celrep.2017.06.037.Link

Relaxation oscillations and hierarchy of feedbacks in MAPK signaling (2017)

Kochańczyk M, Kocieniewski P, Kozłowska E, Jaruszewicz-Błońska J, Sparta B, Pargett M, Albeck JG, Hlavacek WS, Lipniacki T

Scientific Reports doi: 10.1038/srep38244.Link

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton (2017)

Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM.

Cell doi: 10.1016/j.cell.2015.12.042.

Receptor-Level Mechanisms Are Required for EGF-Stimulated ERK Activity Pulses (2015)

Sparta B, Pargett M, Minguet M, Distor K, Bell G, Albeck JG

Journal of Biological Chemistry pii: jbc.M115.662247 Link

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step (2014)

Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW

eLife doi: 10.7554/eLife.03342. Link

Systems biology. Accurate information transmission through dynamic biochemical signaling networks (2014)

Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, Tsimring L, Wollman R

Science 346(6215):1370-3. PDF

Reviews


Experimental and engineering approaches to intracellular communication (2018)

Albeck JG, Pargett M, Davies AE

Essays in Biochemistry doi: 10.1042/EBC20180024. Link

Microenvironmental Signals and Biochemical Information Processing: Cooperative Determinants of Intratumoral Plasticity and Heterogeneity (2018)

Davies AE, Albeck JG

Frontiers in Cell and Developmental Biology 2018 doi: 10.3389/fcell.2018.00044 Link

Mapping the Spectrum of Gene Expression Responses (2016)

Pargett M, Albeck JG

Cell Systems doi: 10.1016/j.cels.2016.04.005. Link

pre-2014


Albeck JG, Mills GB, Brugge JS. (2013)

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.

Molecular Cell 49:1-13. PDF

Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. (2012)

Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57Kip2.

Science Signaling 5(214):ra19. PDF

Hung YP, Albeck JG, Tantama M, Yellen G. (2011)

Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor.

Cell Metabolism 14(4):545-54. PDF

Albeck JG, Brugge JS. (2011)

Uncovering a tumor suppressor for triple-negative breast cancers.

Cell 144(5):638-40. PDF

Spencer SL*, Gaudet S*, Albeck JG, Burke JM, Sorger PK. (2009)

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.

Nature 459(7245):428-32. PDF

Albeck JG*, Burke JM*, Spencer SL, Lauffenburger DA, Sorger PK. (2008)

Modeling a snap-action, variable-delay switch controlling extrinsic cell death.

PLoS Biology 6(12):2831-52. PDF

Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. (2008)

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.

Molecular Cell 30(1):11-25. PDF

Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S.(2006)

Collecting and organizing systematic sets of protein data.

Nature Reviews Molecular Cell Biology 7(11):803-12. PDF