Previous Projects in the Gasser Lab at U. C. Davis

Tomato reproductive genes

 


Immunophilins

Immunophilins were initially discovered in animals as the protein targets of immunosuppressive drugs like cyclosporin and FK506. We were the first to publish on cyclophilins (targets of cyclosporin) from higher plants (Gasser et al., 1992). Following our initial isolation of cyclophilin genes, we continued to study the nature and function of plant cyclophilin and FK506-binding protein. We demonstrated chloroplast localization of one form of Arabidopsis cyclophilin (Lippuner et al. 1994) We identified a gene encoding a novel high molecular weight form of FKBP (Vucich and Gasser, 1996). We performed a comprehensive analysis of the phylogenetic relationships among all known cyclophilins (Chou and Gasser, 1997). In an offshoot of this research we identified two different Arabidopsis zinc-finger transcription factors that could confer salt tolerance on yeast (Lippuner et al. 1996).

If you have the Chime plug-in installed for your browser (available from MDL Information Systems, Inc) you can click here to view a fully interactive model of human cyclophilin A.

 

 

Immunophilin Papers

Datasets we have used for phylogenetic analysis (Chou and Gasser, 1997) of known cyclophilins and cyclophilin-related proteins (as of Mar. 1997) can be viewed or downloaded from this page.


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